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The DNA within a human oocyte encompasses some fifteen million nucleosomes — wrapping 2 times around each one — forming an structured structure termed chromatin.
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This permits the oocytes to pause their development and enter a holding pattern, which lasts in to the mouse’s adulthood. In mice lacking PRC1, the oocytes didn’t pause their advancement; in its place, they withered and died inside a month, leaving the mice permanently infertile.
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Huge protein devices, named chromatin remodelers, can change the positions of spools up and down the DNA thread, therefore facilitating the expression — or silencing — of Countless genes.
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